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Document type:
journal article 
Author(s):
Heid, IM; Jackson, AU; Randall, JC; Winkler, TW; Qi, L; Steinthorsdottir, V; Thorleifsson, G; Zillikens, MC; Speliotes, EK; Mägi, R; Workalemahu, T; White, CC; Bouatia-Naji, N; Harris, TB; Berndt, SI; Ingelsson, E; Willer, CJ; Weedon, MN; Luan, J; Vedantam, S; Esko, T; Kilpeläinen, TO; Kutalik, Z; Li, S; Monda, KL; Dixon, AL; Holmes, CC; Kaplan, LM; Liang, L; Min, JL; Moffatt, MF; Molony, C; Nicholson, G; Schadt, EE; Zondervan, KT; Feitosa, MF; Ferreira, T; Allen, HL; Weyant, RJ; Wheeler, E; Woo...    »
 
Title:
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. 
Abstract:
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VE...    »
 
Journal title abbreviation:
Nat Genet 
Year:
2010 
Journal volume:
42 
Journal issue:
11 
Pages contribution:
949-60 
Language:
eng 
Print-ISSN:
1061-4036 
TUM Institution:
Institut für Humangenetik