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Dokumenttyp:
journal article 
Autor(en):
Voight, BF; Scott, LJ; Steinthorsdottir, V; Morris, AP; Dina, C; Welch, RP; Zeggini, E; Huth, C; Aulchenko, YS; Thorleifsson, G; McCulloch, LJ; Ferreira, T; Grallert, H; Amin, N; Wu, G; Willer, CJ; Raychaudhuri, S; McCarroll, SA; Langenberg, C; Hofmann, OM; Dupuis, J; Qi, L; Segrè, AV; van Hoek, M; Navarro, P; Ardlie, K; Balkau, B; Benediktsson, R; Bennett, AJ; Blagieva, R; Boerwinkle, E; Bonnycastle, LL; Bengtsson Boström, K; Bravenboer, B; Bumpstead, S; Burtt, NP; Charpentier, G; Chines, PS; C...    »
 
Titel:
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. 
Abstract:
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P<5x10(-8). These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits. 
Zeitschriftentitel:
Nat Genet 
Jahr:
2010 
Band / Volume:
42 
Heft / Issue:
Seitenangaben Beitrag:
579-89 
Sprache:
eng 
Print-ISSN:
1061-4036 
TUM Einrichtung:
r Humangenetik