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Dokumenttyp:
journal article 
Autor(en):
Scheckenbach, K; Papadopoulou, G; Hoffmann, TK; Chaker, A; Bier, H; Schipper, J; Balz, V; Wagenmann, M 
Titel:
The checkpointkinase 2 (CHK2) 1100delC germ line mutation is not associated with the development of squamous cell carcinoma of the head and neck (SCCHN). 
Abstract:
The checkpointkinase 2 (CHK2) is part of the highly conserved ATM-CHK2 signaling pathway, which is activated in response to DNA damage, in particular after double strand breaks which can be caused by carcinogens like smoking. After induction of downstream targets, e.g. the tumor suppressor p53, its activation leads to cell cycle arrest and apoptosis. Recently, the presence of CHK2 germ line mutations, primarily the 1100delC variant, has been reported to be involved in carcinogenesis. The CHK2 11...    »
 
Zeitschriftentitel:
J Negat Results Biomed 
Jahr:
2010 
Band / Volume:
Seitenangaben Beitrag:
10 
Sprache:
eng 
TUM Einrichtung:
Hals-, Nasen-, Ohrenklinik und Poliklinik