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Dokumenttyp:
journal article 
Autor(en):
Schelter, F; Kobuch, J; Moss, ML; Becherer, JD; Comoglio, PM; Boccaccio, C; Krüger, A 
Titel:
A disintegrin and metalloproteinase-10 (ADAM-10) mediates DN30 antibody-induced shedding of the met surface receptor. 
Abstract:
Met, the tyrosine kinase receptor for the hepatocyte growth factor is a prominent regulator of cancer cell invasiveness and has emerged as a promising therapeutic target. Binding of the anti-Met monoclonal antibody DN30 to its epitope induces the proteolytic cleavage of Met, thereby impairing the invasive growth of tumors. The molecular mechanism controlling this therapeutic shedding process has so far been unknown. Here, we report that A Disintegrin And Metalloproteinase (ADAM)-10, but not ADAM...    »
 
Zeitschriftentitel:
J Biol Chem 
Jahr:
2010 
Band / Volume:
285 
Heft / Issue:
34 
Seitenangaben Beitrag:
26335-40 
Sprache:
eng 
Print-ISSN:
0021-9258 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung