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Document type:
journal article 
Author(s):
Chen, W; Beck, I; Schober, W; Brockow, K; Effner, R; Buters, JT; Behrendt, H; Ring, J 
Title:
Human mast cells express androgen receptors but treatment with testosterone exerts no influence on IgE-independent mast cell degranulation elicited by neuromuscular blocking agents. 
Abstract:
Women predominate in the anaphylactic reactions to neuromuscular blocking agents (NMBA). The expression of oestrogen receptors has been demonstrated in mast cells and oestrogen treatment can enhance mast cell degranulation, but the influence of androgens remains largely unclear. Our immunocytochemical study showed the expression of androgen receptor (AR) in mast cells isolated from human foreskin as well as in two human mast cell lines, HMC-1 and LAD2. The amount of AR was most abundant in human...    »
 
Journal title abbreviation:
Exp Dermatol 
Year:
2010 
Journal volume:
19 
Journal issue:
Pages contribution:
302-4 
Language:
eng 
Print-ISSN:
0906-6705 
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie ; Institut für Molekulare Allergologie und Umweltforschung