Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Pennino, D; Eyerich, K; Scarponi, C; Carbone, T; Eyerich, S; Nasorri, F; Garcovich, S; Traidl-Hoffmann, C; Albanesi, C; Cavani, A 
Titel:
IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes. 
Abstract:
Th17 is a newly identified lineage of effector T cells involved in autoimmunity and immune responses to pathogens. We demonstrate in this study the pathogenic role of IL-17-producing CD4(+) T lymphocytes in allergic contact dermatitis (ACD) to skin-applied chemicals. IL-17(+) T cells infiltrate ACD reactions and predominantly distribute at the site of heavy spongiosis. Skin IL-17(+) T cells were functionally and phenotypically heterogeneous: although pure Th17 prevailed in ACD skin, hapten respo...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2010 
Band / Volume:
184 
Heft / Issue:
Seitenangaben Beitrag:
4880-8 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
r Molekulare Allergologie und Umweltforschung; r Dermatologie und Allergologie