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Document type:
journal article 
Author(s):
Hartmann, K; Siebenhaar, F; Belloni, B; Brockow, K; Eben, R; Hartmann, B; Ruëff, F; Schoepke, N; Staubach, P; Weber, A; Maurer, M 
Title:
Effects of topical treatment with the raft modulator miltefosine and clobetasol in cutaneous mastocytosis: a randomized, double-blind, placebo-controlled trial. 
Abstract:
Background Mastocytosis is characterized by the accumulation and activation of mast cells in different organs, most commonly the skin. Miltefosine, a raft modulator, has recently been shown to inhibit the activation of mast cells and to reduce mast cell-driven skin inflammatory responses. Objectives To study the safety and efficacy of topical miltefosine treatment of skin lesions in patients with mastocytosis. Methods Thirty-nine adult patients with mastocytosis with skin involvement were treate...    »
 
Journal title abbreviation:
Br J Dermatol 
Year:
2010 
Journal volume:
162 
Journal issue:
Pages contribution:
185-90 
Language:
eng 
Print-ISSN:
0007-0963 
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie