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Document type:
journal article 
Author(s):
Filser, JG; Bhowmik, S; Faller, TH; Hutzler, C; Kessler, W; Midpanon, S; Pütz, C; Schuster, A; Semder, B; Veereshwarayya, V; Csanády, GA 
Title:
Quantitative investigation on the metabolism of 1,3-butadiene and of its oxidized metabolites in once-through perfused livers of mice and rats. 
Abstract:
The industrial chemical 1,3-butadiene (BD) is a potent carcinogen in mice and a weak one in rats. This difference is generally related to species-specific burdens by the metabolites 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB), and 3,4-epoxy-1,2-butanediol (EBD), which are all formed in the liver. Only limited data exist on BD metabolism in the rodent liver. Therefore, metabolism of BD, its epoxides, and the intermediate 3-butene-1,2-diol (B-diol) was studied in once-through perfused liv...    »
 
Journal title abbreviation:
Toxicol Sci 
Year:
2010 
Journal volume:
114 
Journal issue:
Pages contribution:
25-37 
Language:
eng 
Print-ISSN:
1096-6080 
TUM Institution:
Institut für Toxikologie und Umwelthygiene