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Document type:
journal article 
Author(s):
Jawerka, M; Colak, D; Dimou, L; Spiller, C; Lagger, S; Montgomery, RL; Olson, EN; Wurst, W; Göttlicher, M; Götz, M 
Title:
The specific role of histone deacetylase 2 in adult neurogenesis. 
Abstract:
Gene expression changes during cell differentiation are thought to be coordinated by histone modifications, but still little is known about the role of specific histone deacetylases (HDACs) in cell fate decisions in vivo. Here we demonstrate that the catalytic function of HDAC2 is required in adult, but not embryonic neurogenesis. While brain development and adult stem cell fate were normal upon conditional deletion of HDAC2 or in mice lacking the catalytic activity of HDAC2, neurons derived fro...    »
 
Journal title abbreviation:
Neuron Glia Biol 
Year:
2010 
Journal volume:
Journal issue:
Pages contribution:
93-107 
Language:
eng 
Print-ISSN:
1740-925X 
TUM Institution:
Institut für Toxikologie und Umwelthygiene