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Document type:
journal article 
Author(s):
Mutze, K; Langer, R; Becker, K; Ott, K; Novotny, A; Luber, B; Hapfelmeier, A; Göttlicher, M; Höfler, H; Keller, G 
Title:
Histone Deacetylase (HDAC) 1 and 2 Expression and Chemotherapy in Gastric Cancer. 
Abstract:
BACKGROUND: Histone deacetylases (HDACs) modulate chromatin and may influence the effect of DNA-damaging drugs. We investigated HDAC1 and -2 expression in gastric carcinomas (GCs) for an association of patient outcome with conventional neoadjuvant chemotherapy. In vitro, HDAC inhibitors were evaluated as alternative treatment options. METHODS: HDAC1/2 expression was analyzed immunohistochemically in 127 pretherapeutic biopsy samples of neoadjuvant (platinum/5-fluorouracil) chemotherapy-treated G...    »
 
Journal title abbreviation:
Ann Surg Oncol 
Year:
2010 
Journal volume:
17 
Journal issue:
12 
Pages contribution:
3336-43 
Language:
eng 
Print-ISSN:
1068-9265 
TUM Institution:
Institut für Toxikologie und Umwelthygiene