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Dokumenttyp:
journal article 
Autor(en):
Rosemann, M; Ivashkevich, A; Favor, J; Dalke, C; Hölter, SM; Becker, L; Rácz, I; Bolle, I; Klempt, M; Rathkolb, B; Kalaydjiev, S; Adler, T; Aguilar, A; Hans, W; Horsch, M; Rozman, J; Calzada-Wack, J; Kunder, S; Naton, B; Gailus-Durner, V; Fuchs, H; Schulz, H; Beckers, J; Busch, DH; Burbach, JP; Smidt, MP; Quintanilla-Martinez, L; Esposito, I; Klopstock, T; Klingenspor, M; Ollert, M; Wolf, E; Wurst, W; Zimmer, A; de Angelis, MH; Atkinson, M; Heinzmann, U; Graw, J 
Titel:
Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice. 
Abstract:
A new spontaneous mouse mutant was characterized by closed eyelids at weaning and without apparent eyes (provisional gene name, eyeless; provisional gene symbol, eyl). The mutation follows a recessive pattern of inheritance and was mapped to the region of chromosome 19 containing Pitx3. Genetic complementation tests using Pitx3 ( ak/+ ) mice confirmed eyl as a new allele of Pitx3 (Pitx3 ( eyl )). Sequencing of the Pitx3 gene in eyl mutants identified an inserted G after cDNA position 416 (416in...    »
 
Zeitschriftentitel:
Mamm Genome 
Jahr:
2010 
Band / Volume:
21 
Heft / Issue:
1-2 
Seitenangaben Beitrag:
13-27 
Sprache:
eng 
Print-ISSN:
0938-8990 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene; r Allgemeine Pathologie und pathologische Anatomie; r Dermatologie und Allergologie