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Dokumenttyp:
journal article 
Autor(en):
Edling, CE; Selvaggi, F; Buus, R; Maffucci, T; Di Sebastiano, P; Friess, H; Innocenti, P; Kocher, HM; Falasca, M 
Titel:
Key role of phosphoinositide 3-kinase class IB in pancreatic cancer. 
Abstract:
Phosphoinositide 3-kinase (PI3K) signaling is well established as important in cancer. To date most studies have been focused on the PI3K/p110? isoform, which has been found to be mutated in several different cancers. The aim of our study was to determine which specific PI3K isoforms are involved in pancreatic ductal adenocarcinoma (PDAC) and investigate the effects of these isoforms on proliferation, survival, and induction of Akt activation in pancreatic cancer cells.The expression of all PI3K...    »
 
Zeitschriftentitel:
Clin Cancer Res 
Jahr:
2010 
Band / Volume:
16 
Heft / Issue:
20 
Seitenangaben Beitrag:
4928-37 
Sprache:
eng 
Print-ISSN:
1078-0432 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik