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Dokumenttyp:
journal article 
Autor(en):
Su, Y; Loos, M; Giese, N; Hines, OJ; Diebold, I; Görlach, A; Metzen, E; Pastorekova, S; Friess, H; Büchler, P 
Titel:
PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer. 
Abstract:
Tumour hypoxia activates hypoxia-inducible factor-1 (HIF-1) and indluences angiogenesis, cell survival and invasion. Prolyl hydroxylase-3 (PHD3) regulates degradation of HIF-1?. The effects of PHD3 in tumour growth are largely unknown.PHD3 expression was analysed in human pancreatic cancer tissues and cancer cell lines by real-time quantitative PCR and immunohistochemistry. PHD3 overexpression was established by stable transfection and downregulation by short interfering RNA technology. VEGF was...    »
 
Zeitschriftentitel:
Br J Cancer 
Jahr:
2010 
Band / Volume:
103 
Heft / Issue:
10 
Seitenangaben Beitrag:
1571-9 
Sprache:
eng 
Print-ISSN:
0007-0920 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik; r Kinderkardiologie und angeborene Herzfehler