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Dokumenttyp:
journal article 
Autor(en):
Langer, R; Ott, K; Feith, M; Lordick, F; Specht, K; Becker, K; Hofler, H 
Titel:
High pretherapeutic thymidylate synthetase and MRP-1 protein levels are associated with nonresponse to neoadjuvant chemotherapy in oesophageal adenocarcinoma patients. 
Abstract:
BACKGROUND: The aim of this study was to determine whether pretherapeutic protein expression levels of the excision repair cross-complementing (ERCC1) enzyme, thymidylate synthetase (TS), multidrug-resistance protein 1 (MRP-1) and P-glycoprotein (P-gp) are associated with tumour response to cisplatin and fluorouracil (5-FU)-based neoadjuvant chemotherapy in oesophageal adenocarcinomas. METHODS: The expression levels of ERCC1, TS, MDR-1 and P-gp were determined immunohistochemically in pretherape...    »
 
Zeitschriftentitel:
J Surg Oncol 
Jahr:
2010 
Band / Volume:
102 
Heft / Issue:
Seitenangaben Beitrag:
503-8 
Sprache:
eng 
Print-ISSN:
0022-4790 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie; Chirurgiesche Klinik und Poliklinik