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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Obermeier, A; Küchler, S; Matl, FD; Pirzer, T; Stemberger, A; Mykhaylyk, O; Friess, W; Burgkart, R 
Title:
Magnetic Drug Targeting as New Therapeutic Option for the Treatment of Biomaterial Infections. 
Abstract:
Implant-associated infections are a challenging problem in surgery. Bacteria in biofilms are difficult to treat as they are less susceptible to antibiotics or antiseptics which require high drug concentrations at the site of infection. We present a novel strategy to concentrate high antibiotic doses systemically at the target site using newly developed antibiotic-functionalized nanoparticles directed by a magnetic drug-targeting system. The important and effective antibiotic gentamicin served as...    »
 
Journal title abbreviation:
J Biomater Sci Polym Ed 
Year:
2012 
Journal volume:
23 
Journal issue:
18 
Pages contribution:
2321-36 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0920-5063 
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Orthopädie und Sportorthopädie